A simple, precise, accurate, reproducible Second order derivative Spectroscopic method was developed for the estimation of Rivaroxaban in bulk and dosage form. The study was conducted in Methanol. The method was found to be linear in the range of 2-12 μg/ml (r2=0.9998) for Rivaroxaban at λmax=300 nm and λmin=280 nm. The proposed method was validated for linearity, precision, accuracy and ruggedness according to ICH guideline for routine estimation purpose of drug in bulk and dosage form. Since the 2nd derivative method has been developed and validated to ensure that the performance characteristic of the method meets the requirements for the intended analytical applications.
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